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Desktop

Summary

Desktop wallets are downloadable apps capable of operating on Windows, MacOS, or Linux that allow users to interact with their funds.

If you're able to create/sign transactions offline, this is the most-secure method for interacting with the Ethereum blockchain.
Non-custodial, and more private than most other methods of interacting with your funds.

May be more of a hassle when used offline than other methods of accessing your funds.

MyCrypto - Open-source, client-side tool downloadable from https://download.mycrypto.com for generating Ethereum wallets, handling ERC-20 tokens, and interacting with the blockchain easily.
Atomic Wallet - Desktop and mobile wallet that allows you to buy, manage and exchange Bitcoin, Ethereum, XRP and over 300 coins and tokens in one secure interface.
Eidoo - Multicurrency and Multiplatform (Windows, Mac, Linux, Andorid, iOs) wallet with a DEX and a DeFI gateway
Exodus - Closed-source wallet that allows for multi-currency interaction/transacting (requires you to be online to generate transactions).
Fetch - Desktop (and web) wallet supporting Ethereum and ERC-20 tokens. Integrated with 20 exchanges for real time trading rates and one-click trading.
Tokenary - a macOS Ethereum and ERC-20 tokens wallet and Safari extension that lets you store your assets and interact with DApps.
HUT34 - An Ethereum web-based wallet.